Abstract

EMERGING ROLES OF PCSK9 IN THE CENTRAL NERVOUS SYSTEM: THERAPEUTIC TARGET FOR NEUROLOGICAL DISORDERS

Shikha Mishra, Dr. Sajidul Hoque*, Agnes Sara Shibu and Rohit Singh Deo

ABSTRACT

The important cholesterol metabolism regulator PCSK9 has come to light as a possible participant in a number of biological processes, such as autophagy, apoptosis, inflammation, and tumour immunity. PCSK9 is largely recognized for its function in lipid metabolism, but its connection to neurological conditions is gaining more and more attention. PCSK9 expression is raised in the brains of patients with neurodegenerative disorders, which are typified by the gradual death of neurons. Clinical research has repeatedly shown that patients with neurological illnesses have greater levels of PCSK9, which is frequently associated with a worse prognosis. Research, both pre-clinical and clinical, has further linked PCSK9 to the etiology of brain disorders. The many functions of PCSK9, especially in the central nervous system, are explored in this review, with an emphasis on neurodegenerative illnesses. We talk about the genetic variants, functions, and makeup of PCSK9. Furthermore, we investigate the possible influence of increased levels of PCSK9 in the cerebrospinal fluid (CSF) on the expression of neuronal receptors and neuroinflammation. Lastly, we emphasize how PCSK9 inhibitors may be used therapeutically to treat neurological conditions.

Keywords: Proprotein convertase subtilisin, Neurological Disorders, AD, Parkinson's disease, Epilepsy, Stroke.