Abstract

PHARMACOLOGICAL EVALUATION OF FAGOPYRUM ESCULENTUM FOR ANXIOLYTIC ACTIVITY IN ANIMAL MODEL

*Nikita M. Thakare, Prof. Dr. Nitin I. Kochar and Prof. Payal A. Mor

ABSTRACT

An abnormal sense of fear, uncertainty, and concern is known as anxiety. There is an uncomfortable feeling of tension and potential risk. It could be defined as a specific type of behavioural inhibition that occurs in reaction to unknown environmental circumstances. One-eighth of the world's population suffers from anxiety, which has grown significantly in importance as a research topic in psychopharmacology during the past ten years (R. S. Adnaik, P. T. Pai, et. al, July-September 2009). Anxiety is "an emotion marked by feelings of tension, anxious thoughts, and bodily changes including elevated blood pressure, "according to the American Psychological Association (APA). It might be easier to recognise and get treatment for an anxiety problem if one knows the difference between typical anxious emotions and an anxiety disorder that needs medical attention (A. Felman 2020).It can be a typical response to stress. Patient could have anxiety, for instance, when confronted with a challenging challenge at work, before taking a test, or before making a crucial decision. It may enable Patient to manage. Patient could feel more energised or able to concentrate if Patient is anxious. But for some with anxiety disorders, the terror can be incapacitating and last for a long time (National Library Of Medicine 2020). Given the involvement of numerous CNS chemical mediators, there are numerous ways to explain how anti-anxiety medications work. The majority of anxiolytic drugs work by making it easier for GABA-activated chloride channels to open, which improves the response to GABA. The direct stimulation of GABAA receptors, which were related to anxiety, would have an anti-anxiety response. Additionally, the limbic system, hypothalamus, and brain stem reticular system have all been proven to be affected by anti-anxiety medications (R. S. Adnaik, P. T. Pai, et. al, July-September 2009).

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