Abstract

FORMULATION AND EVALUATION OF ABLEMOSCHUS FIBOLECUS TABLET AS IMMUNOMODULATOR (ANTICANCER) ACTIVITY

Abhijeet Arvind Jangam*, Pratik Vijay Kale, Shubham Swami Siddhgavali, Omkar Sunil Jadhav, Nilambari Sudhakar Jadhav, Amruta Anil Nikam and Sanjana Ravindra Gujale

ABSTRACT

Abelmoschus ficulneus, commonly known as the white wild musk mallow, is native to tropical and subtropical regions. It is found in various parts of the world including: Africa: Particularly in tropical regions, Asia: Including India, Sri Lanka, and parts of Southeast Asia, Australia: Especially in northern and central regions, Pacific Islands: In various locations with suitable climates. The plant typically grows in grasslands, along roadsides, and in other disturbed areas where it can thrive in full sunlight. To prepare Abelmoschus ficulneus root into powder, follow these steps: Harvesting: Carefully dig up the roots of the Abelmoschus ficulneus plant, Cleaning: Wash the roots thoroughly to remove soil and impurities. Use a brush if necessary to ensure they are clean, Drying: Air Drying: Spread the cleaned roots on a clean surface in a well-ventilated area, away from direct sunlight. Turn themoccasionally to ensure even drying. This process can take several days. Oven Drying: If you prefer a quicker method, you can use a dehydrator or an oven set at a low temperature (around 100-110°F or 38-43°C). Place the roots on a baking sheet and dry them for several hours until they are completely dry and brittle, Grinding: Once the roots are fully dried, break them into smaller pieces, Use a grinder, food processor, or a mortar and pestle to grind the dried roots into a fine powder. Storing: Store the powder in an airtight container in a cool, dry place. Properly stored, the powder should retain its potency for several months. Make sure to label the container with the name and date of preparation. Collecting natural honey involves several steps to ensure you gather it safely and effectively: Equipment Needed: Beekeeping suit or protective clothing, Smoker, Hive tool, Bee brush, Honey extractor (optional),Uncapping knife or form, Honey strainer or cheesecloth, Containers for honey. Steps to Collect Honey: Prepare and Protect: Wear your beekeeping suit or protective clothing to avoid bee stings, Light the smoker and puff smoke into the hive entrance and under the cover to calm the bees. Open the Hive: Use the hive tool to carefully open the hive. Remove the frames one by one, starting from the outermost frame. Inspect the Frames: Check each frame to ensure the honey is capped (the bees seal the cells with wax when the honey is ready), Only harvest frames that are at least 80% capped. Remove the Bees: Gently brush the bees off each frame with the bee brush, Place the frames with capped honey in an empty box covered with a cloth to keep bees out. Extract the Honey: Manual Method: Use an uncapping knife or fork to remove the wax caps from the honeycomb cells. Then, scrape the honey and comb into a container and strain through cheesecloth to separate the honey from the wax, Using an Extractor: Place the uncapped frames in a honey extractor. Turn the extractor to spin the honey out of the comb. Strain the extracted honey through a fine mesh strainer or cheesecloth to remove any remaining wax and impurities. Store the Honey: Pour the strained honey into clean, airtight containers, Label the containers with the date of collection. Store in a cool, dry place away from direct sunlight. Important Tips: Harvest honey during the appropriate season, usually late summer or early autumn, when the bees have had time to collect and cap the honey, Avoid taking too much honey, leaving enough for the bees to survive the winter, Handle the bees and frames gently to avoid harming the bees or damaging the comb. By following these steps, you can collect natural honey safely and efficiently. Combining honey with jaggery and ghee in tablets is a traditional method used in some cultures to enhance the medicinal properties and efficacy of the ingredients. Here’s a general approach to preparing such tablets:Ingredients:Natural honey, Jaggery (unrefined cane sugar), Ghee (clarified butter). Equipment: Mixing bowl, Mortar and pestle or grinder, Measuring spoons Tablet mold or small scoop, Airtight container for storage. Steps:-Prepare the Ingredients:Grate or finely chop the jaggery to make it easier to mix, Ensure the ghee is at room temperature for easy blending. Mix the Ingredients:In a mixing bowl, combine equal parts of honey, jaggery, and ghee. For example, if you use 1 tablespoon of honey, use 1 tablespoon of jaggery and 1 tablespoon of ghee, Mix thoroughly until you have a smooth, homogenous mixture. Form the Tablets: If you have a tablet mold, fill each cavity with the mixture and press down firmly to compact it, If you don’t have a mold, use a small scoop or your hands to shape the mixture into small, bite-sized tablets. Dry the Tablets (Optional):If the mixture is too sticky, you can dry the tablets slightly by leaving them in a cool, dry place for a few hours, Alternatively, refrigerate the tablets to help them firm up. Store the Tablets:Place the tablets in an airtight container, Store in a cool, dry place, away from direct sunlight. Benefits: Honey: Known for its antimicrobial and antioxidant properties, Jaggery: Rich in minerals and can aid digestion and boost energy levels, Ghee: Known for its anti-inflammatory properties and is a good source of healthy fats.

Keywords: Used of abelmoschus ficulneus roots and Honey with (jaggery and ghee) to used for anti Cancer activity.