Abstract

FORMULATION AND IN VITRO CHARACTERIZATION OF TAMARINDUS INDICA PHYTOSOMES FOR TOPICAL GELS

Anupriya V. and Sowmya C.*

ABSTRACT

The objective of the study is to prepare and evaluate phytosomes of Tamarindus indica leaf extract (TLE) and subsequently convert the phytosomes in to topical gels. TLE phytosomes are prepared by using thin lipid film hydration technique and found it was suitable for their reproducible production. Characterization studies revealed that phytosomes size range is from 321 to 420 nm, poly dispersity index (PDI) is from 0.2 to 0.7. SEM studies revealed that the prepared TLE phytosomes are found in groups and smooth surface texture. Developed phytosomes were converted into topical gels, three batches were prepared by changing the concentration of ethyl cellulose. Topical gels possess required viscosity (3352 to 4989 cps) and pH (5.7 - 6.2) with good spreadability 66.88 to 89.90 cm2. Hence developed gels were found suitable for the topical administration to relieve from inflammation.

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