Abstract

FORMULATION DEVELOPMENT AND DISSOLUTION PROFILE ENHANCEMENT OF POORLY WATER-SOLUBLE DRUG ALLOPURINOL AS TABLET

K. J. Suthar*

ABSTRACT

Objective: Allopurinol is the xanthine oxidase inhibitor drug mainly prescribed for the acute or chronic gouty arthritis attacks and hyperuricemia. The major drawback with this drug is poor bioavailability after oral administration, as it is poorly water soluble drug. The main objective of the present study was to investigate the possibility of improving the water solubility and dissolution profile of Allopurinol by preparing solid dispersions with various water-soluble polymers. To improve solubility of allopurinol drug, as it is poorly water soluble drug. Rapid onset of action which is required in treatment of acute attacks of gout. Experimental work: Solid dispersions of allopurinol with Poloxamer F-127, Polyethylene glycol 4000 and Polyvinyl Pyrolidone K30 were prepared by different methods and evaluated with a view to increase its water solubility and hence to improve the dissolution profile. Solid dispersions were prepared and evaluated for Flow Properties, Solubility and In-vitrodissolution study. One ratio of solid dispersion was selected and formulated into tablet. The tablets were exposed to routine quality control tests Prepared Tablets were compared with marketed tablet. Result and Discussion: All solid dispersions were compatible by evaluating them on DSC study. No drug-excipients interaction was found. Solid dispersion of Drug with PVP K30 was selected as best ratios to prepare Tablets. Tablets were showing better In-vitro dissolution. All results were significant with each other. Conclusion: Solid dispersion Technique efficiently increases the Solubility and Dissolution Profile of Poorly water-soluble drug Allopurinol.

Keywords: Allopurinol, Dissolution, DSC, PVP K30, Solvent evaporation.