Abstract

REVIEW ON: ? CARBOLINE AS AN POTENTIAL ANTINEOPLASTIC AGENT

Durga Bhakad*, Sushama Vaishnav, Pravin Wakte and Sachin Bhusari

ABSTRACT

Cancer is the leading cause of death worldwide and places a significantstrain on the healthcare system. Chemotherapy is one of the manytreatment approaches that are crucial to addressing the difficulties oftreating cancer, particularly when it is discovered at a late stage.Nonetheless, restrictions such severe side effects and drug resistancelinked to current medications have spurred the creation of innovativechemotherapeutic medicines. Indole alkaloids with a tricyclic pyrido[3, 4-b] indole ring in their structure is known as b-carbolines. b-Carboline derivatives have established themselves as promising leadcompounds for the synthesis of various anticancer active agents due totheir widespread availability from natural sources, structural flexibility,quick reactivity, and interaction with varied anti-cancer targets such asDNA (intercalation, groove binding, etc.), enzymes (GPX4, topoisomerases, kinases, etc.),and proteins (tubulin, ABCG2/BRCP1, etc.). The synthesis and isolation, anticancer activity,mode of action, and surface area ratio (SAR) of different compounds containing b-carboline,as well as its derivatives and congeners, are covered in the current review.

Keywords: b carboline, DNA topoisomerase, Peganum harmala, (Zygophillaceae, combilexin.