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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

DEVELOPMENT AND VALIDATION OF A SIMULTANEOUS HPLC METHOD FOR QUANTIFICATION OF ATENOLOL AND AMLODIPINE BESYLATE IN TABLETS

Rashid R. Munjewar, Sayyed Hussain

ABSTRACT

A Reverse phase method has been developed for the quantitative estimation of Atenolol and Amlodipine Besylate in Tablets. The Quantification was carried out using RP stainless steel column ODS C18 250 x 4.6 x 5 μ L1 packing in Isocratic mode with mobile phase containing 0.03 M potassium buffer: Acetonitrile in the ratio of 50:50 Adjust pH3.5 with ortho-phosphoric acid. Degas this solution before use. Flow rate 1.0 ml/minute and the detection wavelength was set at 237 nm and the linearity was found to be in the range of 16-22 μg/ml for Atenolol and 8 to 12 μg/ml for Amlodipine Besylate. The proposed method was found to be simple, precise, accurate, reproducible for the Estimation of Atenolol and Amlodipine Besylate .

Keywords: Atenolol and Amlodipine Besylate Method development Validation, High performance liquid chromatography.

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