Abstract

STUDY OF HEPOTOPROTECHIVE ACTIVITY OF AMYRANTHUS VIRIDIS LEAVES

*Sangeeta Rajput and Dr. Ashish Dixit

ABSTRACT

To Study of Hepotoprotechive Activity of amyranthus Viridis Leaves. Methanolic Extract of amyranthus Viridis Leaves (MeAv) was screened for hepatoprotective activity in PCM (3 g/kg) induced hepatotoxicity in Wistar rats for 15 days at dose of 200 and 400 mg/kg by measuring liver marker enzymes (serum glutamate pyruvate transaminase and serum glutamate oxaloacetate transaminase), bilirubin (total bilirubin and direct bilirubin) and albumin (ALB), total protein (TP) levels and histopathological studies. MeAv significantly (P<0.001) decreases the elevated liver marker enzymes (serum glutamate pyruvate transaminase and serum glutamate oxaloacetate transaminase), bilirubin (total bilirubin and direct bilirubin) and restores albumin (ALB), total protein (TP) levels. A histopathological study also showed liver protective activity of MeAv. In conclusion, administration of MeAv for15 days showed liver protective activity against paracetamol induced liver damage and the potential antioxidant property of MeAv thought to be the mechanism behind its hepatoprotective activity.

Keywords: Amaranthus viridis Linn; Paracetamol; Liver protective activity.