Abstract

EDIBLE VACCINES: A REVOLUTIONARY APPROACH TO DISEASE PREVENTION [A COMPREHENSIVE REVIEW]

Jaydeep Jagannath Chemate*, Swati Rawat, Krishnakant Choure, Pravin Wakte, Sachin Bhusari and Sushma Vaishnav

ABSTRACT

Edible vaccines represent a paradigm shift in the prevention of infectious diseases, offering a cost-effective, easy-to-administer, and safe alternative to traditional vaccines. This review provides a comprehensive overview of the concept of edible vaccines, their potential benefits, and the challenges associated with their development and implementation. The review discusses the various diseases that can be targeted by edible vaccines, including malaria, measles, cholera, hepatitis B, rabies, diarrhea, cancer, autoimmune diseases, rotavirus, anthrax, and HIV. The different types of edible vaccines, including transgenic plants, plant-based vaccines, and edible vaccine tablets, are also explored. The benefits of edible vaccines, including their ease of administration, cost-effectiveness, and safety, are discussed in detail. The review also highlights the challenges associated with edible vaccines, such as dosage variability, immunotolerance, stability, denaturation, distinguishing vaccine from non-vaccine, plant selection challenges, and allergic reactions. Regulatory and ethical considerations surrounding the development and use of edible vaccines are also explored, including the need for strict regulations to ensure public safety and prevent unintended consequences. The current state of edible vaccine development is reviewed, including the results of animal studies and human clinical trials. The review also discusses future directions for research, including the need for further studies to overcome the challenges associated with edible vaccines and to fully realize their potential. Overall, this review provides a comprehensive overview of edible vaccines, their potential benefits, and the challenges associated with their development and implementation. It highlights the need for further research and regulatory frameworks to fully realize the potential of edible vaccines in preventing infectious diseases. Edible vaccines represent a paradigm shift in disease prevention, offering a cost-effective, easy-to-administer, and safe alternative to traditional vaccines. This review explores the benefits, challenges, and applications of edible vaccines, including their potential to prevent diseases such as malaria, measles, cholera, hepatitis B, rabies, diarrhea, cancer, autoimmune diseases, rotavirus, anthrax, and HIV. Regulatory and ethical considerations are also discussed. Despite challenges, edible vaccines have shown promise in animal studies and human clinical trials, making them a promising tool in the fight against infectious diseases.

Keywords: Edible vaccines, Plant-based vaccines, Biotechnology, Vaccine technology, Genetic engineering.