Abstract

SELF-EMULSIFYING DRUG DELIVERY SYSTEMS: A REVIEW

Gauri Dhamale*, Rupali Handal, Prashant Bhukan and Harshali Shelke

ABSTRACT

There are number of new drug candidates developing which has poorwater solubility and the oral delivery of such drugs is frequentlyassociated with implications of low bioavailability, high intra andinter-subject variability, and lack of dose proportionality. Thesolubility of such drug is increased by formulating self-emulsifyingdrug delivery system. Self-emulsifying drug delivery systems(SEDDSs) have gained exposure for their ability to increase solubilityand bioavailability of poorly water soluble drugs. SEDDS are mixturesof oils and surfactants, ideally isotropic, and sometimes containingcosolvents, which emulsify to produce fine oil-in-water emulsionsupon gentle agitation. SEDDSs typically produce emulsions with adroplet size between 100–300 nm. Thus, for lipophilic drugcompounds that exhibit dissolution rate-limited absorption, thesesystems may offer an improvement in the rate and extent of absorptionand result in more reproducible blood-time profiles. Purpose of thisreview article is to provide brief outline of self-emulsifying drug delivery system & itspotential to increase the bioavailability of poorly soluble drugs.

Keywords: Self emulsifying drug delivery system, SEDDS, bioavailability, lipophilic, SMEDDS, SNEDDS.