Abstract

A SYSTEMATIC REVIEW ON NANOSPONGES FOR DRUG DELIVERY

Shivshankar Rengade*, Swati Rawat, Pravin Wakte and Sachin Bhusare

ABSTRACT

The abstract provides an overview of cyclodextrin-based nanosponges, highlighting their significance in nanotechnology and drug delivery. Nanosponges, microscopic structures composed of hyper-cross-linked cyclodextrins, exhibit a unique porous network that can encapsulate a variety of substances. They enhance drug solubility, stability, and bioavailability, offering controlled release and reduced toxicity in medical applications. Methods of synthesis, including hyper-cross-linking and emulsion solvent diffusion, influence their properties. Characterization techniques such as solubility studies and microscopy confirm their structure and functionality. Applications span from cancer therapy to environmental cleanup, showcasing their versatility in addressing complex healthcare and environmental challenges. Future prospects emphasize their potential in combination therapiesand targeted drug delivery systems. Cyclodextrin-based nanosponges thus emerge as pivotal tools in advancing therapeutic efficacy and biomedical innovation.

Keywords: Nanosponges, ?-cyclodextrin, crosslinking, bioavailability, solubility.