Abstract

A REVIEW ON-PHYTOCHEMICAL AND PHARMACOLOGICAL ACTIVITY OF TINOSPORA CORDIFOLIA

Ravi Kumar Vishwakarma, Kamran Javed Naquvi* and Deepak Kumar

ABSTRACT

Medicinal plant Tinospora cordifolia has been used in herb medicine to treat various diseases for a long time. The Pharmacological activities of the ethanolic extract of T. cordifolia specially leaves TC extract the pharmacological potential against hepatoprotective and antioxidant and ethanolic extract of stem of T. cordifolia against anticancer drug cyclophosphamide. Cyclophosphamide (CPP) is an immunosuppressive agent, generally prescribed in treatment of various types of cancer, autoimmune disorders and also to stabilise the organ transplantations. The major setback of the CPP is that it undergoes extensive hepatic metabolism and transformed into active metabolites 4- hydroxycyclophosphamide, phosphoramide mustard and acrolein. Cyclophosphamide and its produced metabolites altogether alter the hepatocellular membrane permeability by initiating lipid peroxidation and leads hepatic injuries. Present study was conducted to establish thehepatoprotective potential of ethanolic extract of stem of Tinospora cordifolia extract (ETCE) against CPP induced hepatotoxicity. The histological results confirmed the hepatoprotective effects of the TC extract. In conclusion, the TC extract showed a hepatoprotective activity in the TAA-treated rats by its powerful antioxidant potential.

Keywords: Medicinal Plant extract, Tinospora cordifolia, phytoconstituents compound, biological effects, pharmacological activities.