Abstract

REPURPOSING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS FOR THE TREATMENT OF TYPE II DIABETES MELLITUS

Shruti Balkrishna Pai* and Darshan Ramkrishna Barhate

ABSTRACT

Drug repurposing is the usage of pre-existing drug candidate for the treatment of new medical condition. The following article deals with the repurposing of Non-Steroidal Anti-Inflammatory Drugs in managing Type 2 Diabetes Mellitus (T2DM). The study depicts Mefenamic Acid’s modulation of potassium-sensitive channels, Naproxen’s role as a metal chelator, and Aspirin's effect on hyperglycaemia. Additionally, the article also comprises methodologies, results and discussions that were employed in the experimental studies. Mefenamic Acid stimulates insulin secretion by inhibiting K+ATP channels, revealing its hypoglycaemic effects. Metal complexes of Naproxen exhibited blood glucose-lowering activity in rodent models. Aspirin's antidiabetic effects were studied through clinical observations, focusing on blood sugar levels, glycosuria and ketonuria. The article concludes by presenting the future prospects, including advanced techniques for drug repurposing and the potential therapeutic applications of NSAIDs in targeting inflammation and NF-κB for enhanced glucose and lipid homeostasis in T2DM. Overall, this article provides an understanding that drug repurposing offers a promising role of NSAIDs in diabetes management.

Keywords: Mefenamic Acid, Naproxen, Aspirin, K+ ATP channels, Type II Diabetes Mellitus.