Abstract

DESIGN AND CHARACTERIZATION OF COPROCESSED PARTICLES FOR DEVELOPMENT OF FAST DISSOLVING TABLETS

Sunita Kumari, Anil Nagar, Abhishek Kumar Jain and Umesh Kumar Jain*

ABSTRACT

Tablets are still the most commonly used dosage form because of the ease of manufacturing, convenience in administration, accurate dosing and excellent stability. There is no single-component excipient fulfills all the requisite performance to allow an active pharmaceutical ingredient to be formulated into a specific dosage form. Co-processed excipient has received much more attention in the formulation development of various dosage forms, especially for tablet preparation by direct compression method. A co-processed excipient is a combination of two or more compendial or non-compendial excipients designed to physically modify their properties in a manner not achievable by simple physical mixing, and without significant chemical change. However, in some instances, formation of necessarycomponents may occur, such as in-situ salt formation. Many different co-processing methods may be used, including standard unit operations such as granulation, spray drying, melt extrusion, milling etc. The choice for a specific application will depend on the materials used, their form (e.g. whether dry powders or liquid) and the specific physical properties desired. Likewise, the ratios of the components may vary depending on the desired performance.

Keywords: Monteleukast sodium, Co-processed techniques, Physical mixing, Hydroxypropyl methyl cellulose, Crospovidone and Microcrystalline cellulose.