Abstract

DEVELOPMENT AND CHARACTERIZATION OF ENALAPRIL MALEATE BUCCAL FILMS

K. Kavitha*, A. Siva Kumar, D. Avinash and A. Yasodha

ABSTRACT

The objective of present study was to develop matrix type buccal patch therapeutic systems of Enalapril using natural polymers as matrix formers. Enalapril buccal patches were developed by using solvent casting technique. Various Physico-mechanical parameters like weight variation, thickness, folding endurance, drug content, moisture content, moisture absorption parameters like mucoadhesive strength, force of adhesion, and bond strength were evaluated. An in vitro drug release study was designed, and it was carried out using commercial semipermeable membrane. Results revealed that prepared patches showed good physical characteristics, no drug-polymer interaction was observed. The in vitro release study revealed that F2 formulation showed maximum release in 8 hrs. The release of Enalapril appears to be dependent on lipophilicity of the matrix. Moderately lipophilic matrices showed best release. The predominant release mechanism of drug through the fabricated matrices was believed to be by diffusionmechanism. Based upon the in vitro dissolution data the F2 formulation was concluded as optimized formulation.

Keywords: Buccal patch, Buccal delivery system, Natural and Synthetic polymers, Solvent casting technique, Diffusion mechanism.