Abstract

ANALYSIS OF HYPERGLYCEMIA COMPARING: CORTISOL, GLUCOSE AND INSULIN, USING QUANTUM CHEMISTRY

Verónica Hernández-Fernández, Olivia Alejandra-García-Paz, Edith González-Castillo Yahir Emmanuel Saldaña-Rodriguez, Alexis Yael-López-Cortes, Adrián Mundo-Álvarez, Diana Laura Pino-Dircio and Manuel González-Pérez*

ABSTRACT

Cortisol (CTS) is a steroid hormone secreted by the human adrenal cortex and released into the bloodstream to perform its function in peripheral tissues. This hormone regulates many body processes and shows its main effect after food intake. CTS contributes to glucose (GLU) intolerance and reduces insulin (INS) sensitivity. This hormone acts chronically hypersecreted in metabolic diseases such as Diabetes Mellitus and in emotional states such as stress. As the objective of this research, we use quantum chemistry to analyze hyperglycemia by comparing CTS, GLU and insulin. Hyperchem software was used as a quantum chemistry simulator. The fundamental basis of quantum calculations was the Electron Transfer Coefficient (ETC) theory. To calculate the electrostatic potential (EP), the Plot Molecular Graph method was used in three dimensions. The ETC was calculated bydividing the bandgap by the EP; in conclusion, CTS-INS has stronger interactions than GLU-INS. This difference causes displacement of GLU into the bloodstream, generating HPGL.

Keywords: Cortisol, Glucose, INS, Hyperglycemia, Quantum Chemistry.