Abstract

ANTIPYRETIC ACTIVITY OF AQUEOUS EXTRACTS OF THALICTRUM FOLIOLOSUM RHIZOME ON YEAST INDUCED PYREXIA IN ALBINO RATS

CL. Ringmichon* and Bindu Gopalkrishnan

ABSTRACT

In present investigation, the rhizome of Thalictrum foliolosum DC. of family Ranunculaceae is tested for antipyretic activity. The decoction of the said rhizome is been used by the Naga tribe in curing fever since ancient times. To prove its claim scientifically the present study was done. The effect of aqueous extracts of rhizome was tested on yeast induced pyrexia in albino rats. Prior to the study, acute oral toxicity testing of drug was performed as per OECD guidelines. The drug dosage of 300, 400, & 500 mg/Kg body weight was tried on the fever induced rats. It was compared with the standard drug Paracetamol (150 mg/Kg body wt) fed rats. The aqueous extract of rhizome showed significant antipyretic activity after 2 hours in the dosage of 300 & 400mg/Kg body wt while the dosage 500mg/Kg body wt was effective within one hour compared to the standard paracetamol. Thus, preclinically crude drug of Thalictrum foliolosum was proved to be effective antipyretic agent as claimed by the Nagas.

Keywords: Thalictrum foliolosum, rhizome, antipyretic, paracetamol.