Abstract

FORMULATION AND EVALUATION OF ZIDOVUDINE MICROPARTICLES USING A NOVEL MUCO RETARDANT POLYMER FROM ARTOCARPUS HETEROPHYLLUS

Prof. Dr P. Ajith Kumar* and Gandhi Kinjal Bipinkumar*

ABSTRACT

The current aim of our research work is to isolate a novel biomaterial from fruit pulp of Artocarpus heterophyllus and to evaluate its muco-retard ability by formulating bio-muco dwarfs using zidovudine as model drug. The bio-material was isolated from fruit pulp of Artocarpus heterophyllus by simplified economic process. Six zidovudine loaded bio-micro dwarfs were prepared using various ratios of bio-retardant isolated. Our experimental research showed that the isolated bio-material possesses good mucoadhesive the bio-material also exhibits its synergetic mucoadhesive when combined with sodium carboxy methyl cellulose. Finally the experimental results showed promising observations in terms of particle size, mucoadhesivity and content uniformity. Hence conclusion was drawn that the isolated bio-polymers has shown its potential as bio muco resident for formulating mucoadhesive microparticles. The bio-polymer can serve as potential polymer for formulating various drug loaded microparticles.

Keywords: Zidovudine Bio-Micro Dwarfs, Novel Bio-Muco Resident, Artocarpus heterophyllus.