Abstract

PALLADIUM AND PLATINUM COMPLEXES OF 2-AMINO-N'-[(1E,2Z)-2-(HYDROXYIMINO)-1-PHENYLETHYLIDENE]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOHYDRAZIDE:SYNTHESIS, STRUCTURE, SPECTRAL PROPERTIES AND ANTIMICROBIAL ACTIVITY

K. Aruna, Mobashshera Tariq, Sakina Bootwala*, and Ganesh More 

ABSTRACT

Complexes of Pd(II) and Pt(II) with an asymmetric hydrazones derivative were synthesized from 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3carbohydrazide and (2E)-2-(hydroxyimino)-1-phenylethanone and characterized by analytical analysis and physical-chemical methods.The micro analytical and physico-chemical data suggested the stiochiometry of the Pd(II) 1:2 and Pt(II) 1:1 (metal: ligand) complexes respectively and geometry of these complexes were square planer. These complexes were also screened for their antimicrobial properties against drug resistant extended spectrum β-lactamase and Metallo-β-lactamase producers and it was found to be effective.

Keywords: asymmetric ligand, complexes, beta-lactamase.