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A SMART REVIEW ON TRANSDERMAL PATCHES FOR CONTROLLED DELIVERY OF METFORMIN HYDROCHLORIDE TO IMPROVE DRUG BIOAVAILABILITY VIA TRANSDERMAL ROUTE
Praveen Kumar Ashok, Yogita Tyagi, Hiba Parveen and Monu Kumar?
ABSTRACT
Metformin Hydrochloride (MF HCl), an anti-diabetic drug, has compromised oral absorption due to low permeability resulting in lower bioavailability. Therefore, transfersomes (TFs) were explored as a novel strategy in an attempt to address permeation limitations. MF HCl loaded transfersomes (MF-TFs) were prepared using a modified thin film hydration technique. Prepared MF-TFs were then embedded in Carbopol gel containing permeation enhancer (PE) to improve the drug bioavailability with the potential to combat type 2 diabetes mellitus (DM-II) through the transdermal route. To assess the glucose control of MF-TFs, a glucose tolerance test was performed. The optimized formulation was further characterized by in vitro and as well as ex vivo skin studies. In addition, in vivo studies were also performed in healthy Keywords: Transdermal, Permeation pathways, Drug delivery, Matrix, Reservoir, Transdermal film, Metformine hydrochloride, in vitro evaluation. [Download Article] [Download Certifiate] |