Abstract

ANTI ANXIETY AND ANTI CONVULSANT ACTIVITY OF METHANOLIC EXTRACT OF ENSETE SUPERBUM CHEESM SEEDS

Latha Sundarraj*, Thamotharan G., Dr. Suresh V. and Pavithra Duraisamy

ABSTRACT

The purpose of the current study was to assess the anticonvulsant and anxiolytic properties of a methanolic extract of Ensete superbum seeds (MEES). The anxiolytic action of a methanolic extract of Ensete superbum at dosages of 200 and 400 mg/kg was investigated using the elevated plus maze method (EPM) and open field test (OFT) models, after a basic phytochemical assessment and an acute oral toxicity test. The anticonvulsant effect was investigated using supra maximal electroshock (MES) and pentylenetetrazol (PTZ) initiated seizure models. The number of sections and time spent in open arms in the EPM model, as well as the number of squares crossed and raised rearing in the OFT, were all considerably boosted by oral MEES treatment for seven days. Moreover, MEES (200 and 400 mg/kg) showed a noteworthy decline in the length of the tonic rear limb flexion, expansion, clonus, and stupor during electroshock convulsions; protected the rat from seizures caused by PTZ.

Keywords: Ensete superbum, Anxiolytic, Anticonvulsant, Elevated- plus maze, Open- field test.