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PREPARATION AND EVALUATION OF MICROSPHERES BASED LONG-ACTING DEPOT INJECTION USING A NOVEL BIOMATERIAL AS A POLYMER
Apeksha Saraf*
ABSTRACT The aim of this study was to develop depot formulation of risperidone by employing cholesterol as a rate-retarding carrier. Microspheres were prepared by emulsion-solvent evaporation method. Different formulation variables for solvent evaporation method, viz, effect of theoretical drug loading, concentration of surfactant, presence of gelatin in internal phase and presence of salt in external aqueous phase were optimized. The microspheres were characterized for their encapsulation effeiciency, particle size, surface morphology, drug release profile and drug release kinetics. The optimized formulation showed consistent drug release for upto 15 days time period Keywords: Microspheres, particle size, surface morphology. [Download Article] [Download Certifiate] |