Abstract

PUMPKIN SEED OIL'S POTENTIAL IN TREATING LIVER DAMAGE: AN EXAMINATION OF ITS CONSTITUENTS AND SOLID LIPID NANOPARTICLE DRUG DELIVERY SYSTEM

Ujwala P. Chamat*, Ankita G. Jaunjal and Ashwini R. Raghorte

ABSTRACT

Liver damage and hepatotoxicity present significant challenges in clinical medicine, necessitating innovative therapeutic approaches. This study explores the therapeutic potential of pumpkin seed oil (PSO) in treating liver damage, focusing on its bioactive constituents and the efficacy of its administration via solid lipid nanoparticles (SLNs). Pumpkin seed oil is rich in essential fatty acids, antioxidants, and phytosterols, which contribute to its hepatoprotective properties. The encapsulation of PSO in SLNs enhances its stability, bioavailability, and targeted delivery to liver tissues, thereby maximizing its therapeutic benefits. This paper provides a comprehensive review of the pharmacological constituents of PSO, its mechanisms of action in hepatoprotection, and the advantages of usingSLNs as a drug delivery system. The findings suggest that PSO, when delivered through SLNs, offers a promising alternative for the treatment and management of liver damage, presenting a synergistic approach that leverages natural compounds and advanced pharmaceutical technology. Further research and clinical trials are warranted to validate these findings and to optimize the formulation for clinical use.

Keywords: Hepatotoxicity, Bioactive constituents, Solid Lipid Nanoparticles, Encapsulation, Targeted Delivery, Synergistic approach, Oxidative cells, lipid matrix.