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DIPEPTIDYL PEPTIDASE 4 INHIBITORS (DPP4’S)
Dr. S. Rajini*, Dr. M. Prasadarao, T. Naga Somulu, N. Ashok, G. Lakshmi Narayana and G. Srilakshmi
ABSTRACT
Type 2 diabetes (T2DM) is a progressive disease, and pharmacotherapy with a single agent does not generally provide durable glycaemic control over the long term. Sulphonylurea (SU) drugs have a history stretching back over 60 years, and have traditionally been the mainstay choice as second-line agents to be added to metformin once glycaemic control with metformin monotherapy deteriorates; however, they are associated with undesirable side effects, including increased hypoglycaemia risk and weight gain. Dipeptidyl peptidase (DPP)-4 inhibitors are, by comparison, more recent, with the first compound being launched in 2006, but the class now globally encompasses at least 11 different compounds. DPP-4 inhibitors improve glycaemic control with similar efficacy to SUs, but do not usually provoke hypoglycaemia or weight gain, are relatively free from adverse side effects, and have recently Keywords: . [Download Article] [Download Certifiate] |