Abstract

EFFECT OF COMBINATION OF URSOLIC ACID AND GLIBENCLAMIDEON MACROPHAGE PHAGOCYTIC INDEX IN ALLOXAN INDUCED DIABETIC RATS.

Mr. Amol Kumbhar, Mr. Aniket Garud*, Mr. Ameya Deo, ,Mr. Jeevan Dhumal, Dr. Rajesh Oswal, Dr.Neeraj Vyavahare, Dr.PravinChaudhari

ABSTRACT

Diabetes being a metabolic disorder it modifies immune system not only with type 1 but also in type 2.Immunological aspect in diabetes and related complication needs to be explained for better understanding and better pharmacotherapy of diabetes. The macrophage have their role in various activities viz. response to Vaccines, memory impairment and clearance of plaques in brain, wound healing, role of testicular macrophagesregulating NO production insteroidogenesis and testosterone synthesis,role of melatonin on macrophages and generation of superoxide etc. In present study effect of combination of Ursolic Acid and Glibenclamide on Macrophage Phagocytic Index in Alloxan induced diabetic rats was studied.Considering the results obtained from the present study it can be concluded that the combination of Ursolic Acidhas promising antidiabetic effect along with it will play a beneficial role and can cover wide range of diabetic complications.

Keywords: Ursolic acid, Alloxon , Macrophage phagocytic Index, Immune dysfunction, Diabetic Complications.