Abstract

GELLAN GUM-BASED FLOATING IN-SITU GEL: ADVANCEMENT AND APPLICATION

Gyati Shilakari*, Abhinav U., Siddhartha Reddy L. and Anusha G.

ABSTRACT

A floating drug delivery system is a contemporary method for delivering drugs that consists of mainly a structure that swells, floats, sticks to mucous membranes, and is dense. Their density is less compared to the content of the stomach hence they are retained in it to float above its contents demonstrating discharge and sustaining themselves on the top layer of the gastric fluid creating a long-lasting impact they are applied directly to the site of action On-contact in-situ gels are suspensions or solutions which turn into a gel upon coming into contact with body fluids or due to physicochemical changes at a particular site. The oral floating in-situ gel may simplify the challenges popular in conventional oral dosage forms like reduced bioavailability due to fast gastric transit from the stomach or increased dosing frequency. Controlled release and site-specific delivery capabilities improvement have gained much attention from pharmaceutical researchers in relation to the floating oral in-situ gelling system. This review focuses on the formulations of gellan gum-based floating oral in-situ gelling systems, formulation approaches as well as brief evaluation parameters which are highly advantageous in pharmaceutical formulations.

Keywords: Floating drug delivery, Gellan gum, floating gel, site-specific drug delivery.