Abstract

DESIGN FORMULATION AND EVALUATION OF POLYHERBAL CAPSULE

Dr. Satnam Singh, Mr. Kartikey, Dr. Navjot Kaur, Mrs. Navjit Kaur, Ms. Arshleen Kaur*

ABSTRACT

Objective: The aim of the present study is to develop and evaluate poly herbal capsule prepared for management of diabetes. Methods: Dry herbs of Gymnema sylvestre, Moringa oleifera, Fenugreek, Bitter Melon, Ocimum sanctum, Curcuma longa, Cinnamon cassia, Tinospora cordifolia, Azadarachita Indica, Syzygium Cumini, and Zingiber officinale was collected from local market and powdered. Herbal components were weighed in ascending order of weight using the formula shown below. A mortar and pestle were used to triturate the weighed ingredients. The powdered herbal ingredients were sieved using a 120 mesh screen. The polyherbal formulation in powder form was enclosed. To package the medication (Blended extract) at the intended strength of 150 mg, size #0 capsules were used and The produced formulation passed the tests for bulk density, tapped density, angle of repose, Hausner's ratio, Carr's index, moisture content, weight variation, leak test and disintegration/dissolution. Results: Positive results were obtained in the observed parameters, thus favoring the use of the plants. Pre-formulation study revealed that all the evaluated parameters were found to be within the acceptable limits. Conclusion: Laboratory-scale preparation of polyherbal capsule can lead to new powerful and stable oral dosage formulations for diabetes mellitus and lighten the synergistic area of action of herbs.

Keywords: Anti diabetic, Polyherbal, Gymnema sylvestre, Syzygium Cumini, Moringaoleifera, Capsules.