Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF ANTIFUNGAL HERBAL GEL

Nabamita Basu*, G. Sainuthana, Rasmeen Fathima and A. Lohithalekha Sree
Hephzibha

ABSTRACT

Fungal infections are a pervasive and challenging health issue, impacting millions of individuals globally. With the rise of antifungal resistance and the adverse effects associated with synthetic antifungal agents, there is a growing interest in natural alternatives. This study focuses on the formulation and development of an antifungal herbal gel, leveraging the therapeutic potential of various medicinal plants. The primary objective is to create a topical gel with potent antifungal properties, minimal side effects, and enhanced patient compliance. Fruits and leaves of Schinus terebinthifolius (Brazilian peppertree) were selected for this formulation. The extraction was done by the Maceration and Soxhlet apparatus techniques. The extracts were incorporated into the base gel-prepared formulation prepared in the laboratory. The prepared products were further evaluated for their color, spreadibility, pH, washability, consistency, and zone of inhibition.

Keywords: Maceration, antifungal, Soxhlet apparatus, Base gel, Herbal extractions.