Abstract

mRNA VACCINE DELIVERY SYSTEM

Kajal Sharma*, Jasvinder Saini, Komal Bhardwaj and Satwinder Kaur

ABSTRACT

The development of efficient vaccinations against infectious illnesses has been made possible through mRNA vaccines, which have completely changed area of vaccination. This is demonstrated via efficacy of COVID-19 vaccines. Lipid nanoparticles, an extremely often utilized delivery mechanism, are essential for stability, safeguarding, and effective uptake of mRNA vaccines to target cells. The mRNA molecule themselves, nanoparticles of lipids, and mechanism of action are all covered in detail in this article's summary of elements of mRNA vaccine delivery systems. Notwithstanding its benefits—such as quick development and potent immune responses—mRNA vaccines present a number of difficulties. Concerns about adverse responses, complicated production procedures, for a long-time health and safety requirements, regulatory obstacles, supply
effectiveness, durability and storage, and adverse reactions are on list of issues. For mRNA vaccines to remain as effective and accessible as possible and to spread widely and fairly, such problems must be resolved by continued research and technical developments. With regard to mRNA vaccine delivery methods, this article elucidates their promise as well as their limits, offering future prospects for developing this groundbreaking innovation.

Keywords: mRNA vaccine, lipid nanoparticles, targeted delivery, vaccine delivery system.