Abstract

BILOSOMES - A POTENTIAL NANOCARRIER TO TREAT VARIOUS DISEASES

Pooja Bandi*, Dwarakanadha Reddy Peram and Swarnalatha Dugasani

ABSTRACT

The bilayer structure of nonionic amphiphiles is known as a Bilosome. Comparable to niosomes, which are nonionic surfactant vesicles, are bilosomes. Because they are more stable than regular liposomes and are enhanced with a bile salt, bilosomes represent a new generation of nanovesicles. As an alternative to injectable therapy, oral drug delivery is made feasible by bilosomes, a unique kind of drug delivery system that protects medications from a breakdown in the stomach. Because bilosomes are stable in the gastrointestinal tract, they have been demonstrated to increase biocompatibility and improve therapeutic action. Because entrapped drugs absorb quickly through the gastrointestinal tract and enter the portal circulation, their bioavailability is enhanced. This makes water-insoluble drugs more hydrophilic, which increases their bioavailability. Consequently, bilosomes have been developed as a potential vesicular carrier system for parenteral, transdermal, and oral-targeted drug delivery. This article
provides a brief overview of the new-generation Bilosome drug delivery systems, including their introduction, features, deficiencies, applications, storage stability, and future prospects. It also covers their classification, composition, method of preparation, and characterization of Bilosomes.

Keywords: Bilosomes, Nano vesicle, Bile salt, Non-ionic surfactant, unilamellar, amphiphiles, Biocompatibility.