Abstract

IN-SILICO STUDY OF MONOAMINO OXIDASE INHIBITOR AS AN ANTIDEPRESSANT

*Sneha S. Tidke, Neha O. Mankar, Diksha Ukhare and Dinesh R. Chaple

ABSTRACT

In the present work, 5 compounds of monoamine oxidase inhibitor selected from pubchem database previously reported with potent anti-depressant activity. Molecular docking was performed on all 5 selected compounds. ADME and toxicity screening was also performed. Compound no. 034 obey all the ADME and toxicity rules. Isocarboxazid standard drugs used for where compound no. 03 found more docking score than the standard drug. The results of molecular docking studies could help scientists to propose novel compounds with higher anti-depressant activities. Therefore, they could reduce time, cost and even the availability of the laboratories equipped to carry out the synthesizers and tests.

Keywords: Monoamine oxidase inhibitor, molecular docking, anti-depressant, pubchem.