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AT A GLANCE MECHANISM OF ACTION OF ORAL ANTIDIABETIC DRUGS, A REVIEW
Mohammad Taleb Hossain* and Md. Harun Ar Rashid
ABSTRACT
Diabetes is a chronic metabolic disorder with high mortality rate and with defects in multiple biological systems. Two major types of diabetes are recognized, type 1 and 2. With type 2 diabetes (T2D) being by far the more prevalent type. As diabetes affects multiple biological functions, the use of multiple drug classes with different mechanisms of actions is required to easy understand in order to provide effective therapy. Nine classes of oral antidiabetic agents are used for the management of patients with T2D. These include the insulin secretagogues, biguanides, thiazolidinediones, the alpha-glucosidase inhibitors, incretin-based therapy (Agonists and dipeptidy peptidase 4 (DPP-4) inhibitors), the sodium glucose co-transporter 2 (SGLT 2) inhibitors, the dual peroxisome proliferator-activated receptor (PPAR) agonists, bile acid binding sequestrants and dopamine Keywords: Oral antidiabetic, Type-2 Diabetic Mellitus, Hyperglycemia, Efficacy, Safety etc. [Download Article] [Download Certifiate] |