Abstract

AN RESEARCH REPORT ON ANALGESIC AND ANTI-INFALMMATORY EFFECTIVENESS OF SITAGLIPTIN AND VILDAGLIPTIN IN MICE

Biswanath Prusty* and Suraj Sahoo

ABSTRACT

Hyperglycemia is a hallmark of the chronic, progressive condition known as type 2 diabetes mellitus (T2DM). Dipeptidyl peptidase (DPP) - 4 inhibitors are a unique family of antidiabetic medications that were described for the treatment of type 2 diabetes mellitus. When blood glucose levels rise, the DPP-4 inhibitors promote the combination and release of insulin by blocking the metabolism of the incretin hormones gastric inhibitory polypeptide and glucagon-like peptide 1. The purpose of this study is to assess the safety and efficacy of vildagliptin and sitagliptin as analgesics and anti-inflammatory drugs in mice. The experiment is conducted using a variety of methodologies, including the tail-flick method, the acetic acid-induced rhythmic test method, the formalin-induced paw oedema method, and the tail-flick test data. Analgesic research on mice using sitagliptin and
vildgliptin reveals that sitagliptin is 0–10 times more potent than vildagliptin.

Keywords: Type-2 diabetes mellites, Dipeptidyl peptidase (DPP) - 4 inhibitors, Sitagliptin, Vildagliptin, Tail flick test, Acetic acid induced rhythmic test, Hind paw oedema test.