Abstract

FORMULATION AND EVALUATION OF MOSAPRIDE CITRATE NANOSUSPENSION

Nikhil N. Navindgikar*, Dr. B. D. Tiwari, Gautami A. Durgam, Supriya M. Gadave, Aboli B. Dongare

ABSTRACT

The current research study was aimed at formulation and evaluation of nanosuspension of mosapride citrate. Nanosuspensions are tiny drug particles suspended in a liquid, with surfactants helping stabilize them. They are considered a two-phase system where the drug particles are dispersed in water, with the particle size less than 1 µm. The effectiveness of drugs greatly depends on their solubility. Mosapride citrate, a drug with poor water solubility, can be significantly improved by using nanosuspension technique to reduce the particle size, thereby increasing the rate of dissolution and enhancing the surface area of the drug particles. Mosapride citrate is classified as a class II drug based on the Biopharmaceutics Classification System (BCS), characterized by its low solubility and high permeability. Solubility is a crucial physiochemical component that influences medication absorption and therapeutic efficacy. The nanosuspension was formulated using the nanoprecipitation method, which employed methanol as the solvent and water as the antisolvent. Sodium Lauryl Sulphate (SLS) as surfactant and Polymer Hydroxypropyl methylcellulose (HPMC) were utilized in the formulation. The nanosuspension was evaluated for their particle size, drug content, redispersibility, viscosity, zeta potential, entrapment efficiency and saturation solubility. The Nanoprecipitation method is an efficient approach for creating nano-sized particles of poorly water-soluble medications, resulting in increased solubility.

Keywords: Mosapride citrate, Nanosuspension, Nanoprecipitation method, solubility, particle size.