Abstract

REVIEW ON: MIGRAINE IN PATIENTS WITH INFLAMMATORY BOWEL DISORDERS

Vidhate Samiksha B.*, Gaidhane Shital V. and Kale Disha S.

ABSTRACT

Migraine is a chronic and frequently seen primary headache condition that impacts more than 17% of females and 5%-8% of males. The pathophysiology of migraine is intricate and remains incompletely understood. Recent studies have shown a higher prevalence of gastrointestinal (GI) disorders in migraine patients compared to the general population. Several mechanisms related to the gut-brain axis, such as chronic inflammatory responses with inflammatory and vasoactive mediators entering the circulatory system, modulation of the enteric immunological environment by intestinal microbiota, and dysfunction of the autonomic and enteric nervous systems, have been proposed to elucidate these connections. The complete understanding of the intricate mechanisms and pathways associated with the gut-brain axis in migraine remains to be fully clarified. Migraine has been found to be associated with an increased risk of developing inflammatorybowel disease (IBD) in a recent study published in Scientific Reports. This neurological disorder, characterized by painful headaches, is often under-recognized and undertreated, affecting individuals under the age of 50. The study highlights the potential connection between migraine and gastrointestinal symptoms, as well as the development of IBD(Inflammatory Bowel Disorders) emphasizing the importance of understanding the gut-brain axis in these conditions. Previous research has identified various factors contributing to the risk of IBD(Inflammatory Bowel Disorders)with IBD patients being at a higher risk of experiencing migraine. However, further studies are needed to explore the impact of migraines on the development of IBD. We delve into the potential physiological and pathological mechanisms, explore the clinical implications, and highlight various promising avenues for future research.

Keywords: Migraine, Gastrointestinal disorders, Gut-brain axis, Inflammatory bowel disorders, Microbiota, Crohn's disease, Ulcerative Colitis.