![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
SESAMUM INDICUM AND DEHYDRATED BANANA POWDER IN THE DESIGN OF FAST DISSOLVING TABLETS OF LORAZEPAM
Kore Sandhya, Dr. S.B. Shirsand, Vishnu J. Pawar, Shailari Shirsand
ABSTRACT
In the present study an attempt has been made to elevate the safety and efficacy of drug molecule of fast dissolving tablets of Lorazepam. It was designed with a view to enhance patient compliance by direct compression method. In direct compression method, natural disintegrants such as mucilage of Sesamum Indicum (Sesame), dehydrated banana Powder were used and compared with crospovidone (CP) a synthetic superdisintegrant in different ratios and directly compressible mannitol as a diluent to enhance mouth feel. Estimation of Lorazepam in the prepared tablet formulations was carried out by extracting the drug with methanol and measuring the absorbance at 230 nm. The formulations were further evaluated for various parameters like hardness, drug content uniformity, in-vitro dispersion time, friability, wetting time, water absorption ratio, in-vitro drug release, stability studies (at 400C/ 75% relative humidity for 3 months) and drug-excipients interaction (IR spectroscopy). Three Keywords: Fast dissolving tablets, Lorazepam, Sesamum Indicum (Sesame), dehydrated banana Powder. [Download Article] [Download Certifiate] |