Abstract

A NEW GENERATION OF CHEMOTHERAPEUTICS AGENT AS 5-FU LOADED NANOPARTICLES USED FOR EFFECTIVE CANCER TREATMENT.

Devender Singh, Nikhil Gupta*, Dr. S K Prajapati and Santosh Kumar

ABSTRACT

Combination chemotherapy and nanoparticle drug delivery are two areas that have shown significant promise in cancer treatment. Combined therapy of two or more drugs promotes synergism among the different drugs against cancer cells and suppresses drug resistance through distinct mechanisms of action. Nanoparticle drug delivery, on the other hand, enhances therapeutic effectiveness and reduces side effects of the drug payloads by improving their pharmacokinetics . Nanotechnology is the engineering of functional systems at the molecular scale. This covers both current work and concepts that are more advanced. nanotechnology enhanced materials will enable a weight reduction accompanied by an increase in stability and an improved functionality. Biomedical nanotechnology, bionanotechnology and nanomedicine are used to describe this hybrid field. The pace of new discoveries in biotechnology and health care and even the appearance of whole new fields of endeavour in recent years have made for an exciting and challenging time for pharmacists. The target is always to provide the proper dose of the antitumor agent only at the desired locus of action, thus reducing the unwanted side effects. 5-Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that increase its anticancer activity. Nanotechnology is one of the fast-moving technologies and is presently contributing significantly to the progress of medical science. Drugs categorized under the drug delivery system (DDS) are made primarily by utilizing nanotechnology.

Keywords: Nanoparticles, Combination Chemotherapy, 5-Flurouracil, Cancer treatment, Bionanotechnology and Nanotechnology.