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MUCOADHESIVE MICROSPHERES-A NOVEL APPROACH OF DRUG TARGETING
Venkatesh Gavini*, B. Ragini and K. Kaumudi
ABSTRACT An appropriately designed controlled release drug delivery system can be a major advance towards solving problems concerning to the targeting of drug to a specific organ or tissue and controlling the rate of drug delivery to the target site. The development of oral controlled release systems has been a challenge to formulation scientist due to their inability to restrain and localize the system at targeted areas of gastrointestinal tract. Mucoadhesive microparticulate drug delivery systems are an interesting and promising option when developing an oral controlled release system. In recent years such mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal routes for either systemic or local effects. The objective of this paper is to review the principles underlying the formulation and evaluation of mucoadhesive microspheres and to take a closer look at mucoadhesive microparticles as drug delivery devices for increasing efficiency of drug delivery, improving the residence time and release profile. Keywords: Microparticles, Mucoadhesive microspheres, controlled release [Download Article] [Download Certifiate] |