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INVESTIGATING THE GENOTOXIC EFFECTS OF ETHYLENE OXIDE EXPOSURE AND ITS POTENTIAL ROLE IN CANCER DEVELOPMENT
*Qumre Alam, Akash Johri, Himanshu, Harsh Kumar and Deepak Yadav
ABSTRACT
Ethylene oxide (Eto) is a highly reactive chemical used extensively in industrial processes, notably in the sterilization of medical equipment and the production of chemicals. Despite its utility, Eto is recognized for its genotoxic properties, raising concerns about its potential role in cancer development. This review systematically examines the genotoxic effects of ethylene oxide exposure, focusing on its interaction with DNA, the formation of DNA adducts, and the subsequent mutagenic outcomes. We analyze epidemiological studies, in vitro experiments, and animal models to elucidate the mechanisms by which EtO induces genetic mutations and chromosomal aberrations. Furthermore, we explore the relationship between Eto-induced genetic damage and the initiation and progression of various cancers, Keywords: Ethylene oxide, genotoxicity, DNA adducts, mutagenesis, carcinogenesis, cancer risk, biomarkers, occupational exposure, safety regulations, epidemiology. [Download Article] [Download Certifiate] |