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EFFECT OF ETHANOLIC EXTRACT OF HERBAL PLANT ON SERUM LIPID PROFILE OF HIGH FAT DIET INDUCED HYPERLIPIDEMIA IN WISTAR RATS
Syeda Qadar Unnisa*, Neha Jabeen, Zehra Fatima and Basheer Unnisa
ABSTRACT
The main aim of the study was to evaluate the antihyperlipidemic effect of ethanolic extract of Commiphora mukul and Aconitum heterophyllum against high fat diet induced hyperlipidemia in wistar rats and its efficacy was compared with standard lipid lowering drug (Atorvastatin) The animals were divided into nine groups of six animals in each group. Control group animal receive normal chow diet, hyperlipidemic group or toxic group was given high fat diet whereas, treatment group which EECM 200 mg/kg, EECM 400 mg/kg, EEAH 200 mg/kg, EEAH 400 mg/kg, and combination of EEAH+EECM 200mg/kg, EEAH+EECM 400 mg/kg doses of plant extract was also fed with high fat diet for about 14 days in order to induce hyperlipidemia and then oral dose of standard and extract was given. In hyperlipidemia there is an increase in the level of LDL, VLDL, TG, Keywords: High Fat Diet, Hyperlipidemia, Atorvastatin, Hepatic Steatosis. [Download Article] [Download Certifiate] |