Abstract

REVIEW ON ANALYTICAL METHODS OF LOSARTAN AND HYDROCHLOROTHIAZIDE

Maisuriya Shivani*, Modi Nandini and Dutiya Rumana

ABSTRACT

Systemic arterial hypertension (hereafter referred to as hypertension) is characterized by persistently high blood pressure (BP) in the systemic arteries. BP is commonly expressed as the ratio of the systolic BP (that is, the pressure that the blood exerts on the arterial walls when the heart contracts) and the diastolic BP (the pressure when the heart relaxes). It is a prevalent cardiovascular disorder, often requires a combination of antihypertensive agents for optimal management. Among these combinations, Losartan and Hydrochlorothiazide have gained prominence. Losartan is a type of blood pressure-lowering medicine called an angiotensin receptor blocker. Like other angiotensin receptor blockers, losartan relaxes and widens your blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body. and Hydrochlorothiazide, a thiazide diuretic, synergistically reduce blood pressure. Thus Losartan and hydrochlorothiazide combination is also used to reduce the risk of stroke in patients with high blood pressure and enlargement of the heart. Losartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes the blood vessels to tighten. This review explores about two drugs that have successfully determined the several analytical methods such as in losartan by HPLC, capillary electrophoresis and super-critical fluid chromatography in urine by gas chromatography-mass spectrometry and, simultaneously with its active metabolite in biological fluids by HPLC. And in hydrochlorothiazide by using electrochemical or spectrophotometric methods and jointly with other pharmaceutical substances, including spectrophotometric and HPLC procedures.

Keywords: Hypertension, Losartan potassium, Hdrochlorothaizide, Analytical methods.