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ANTIDIABETIC POTENTIAL WITH ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES FROM THE FRACTIONS OF ETHANOLIC EXTRACT OF TECOMELLA UNDULATA STEM BARK: IN-VITRO STUDY
Nahida Siddiqui*, Gajengi Sri Meghana, Boorugu Aashritha, Bollarapu Ganesh,
ABSTRACT
Traditional herbal medicines, with fewer side effects than modern pharmaceuticals, hold promise for managing diabetes. Phytoconstituents possess protective properties against oxidative stress and inflammation, key factors in Type 2 diabetes mellitus (T2DM). The methanolic fraction of ethanolic extract (25.8%) showed the highest TPC and TFC (2.7 and 9.0 μg of gallic acid and quercetin, respectively). In-vitro assays demonstrated its significant antioxidant activity, inhibiting H2O2-induced oxidation (62.9%±0.38), and substantial anti-inflammatory effects, preventing protein denaturation (51-63%±0.71). The fraction also exhibited notable antidiabetic potential by enhancing glucose uptake in yeast cells at 80 mg/ml (68.57%±0.71) and 100 mg/ml (76.59%±0.62) with 5 mM glucose, and at 80 mg/ml (59.63%±0.21) and 100 mg/ml (67.51%±0.82) with 10 mM glucose. Additionally, IC50 value of the methanolic fraction against α-glucosidase enzyme was 139.56 µg/ml, surpassing the effect of acarbose (145.23 µg/ml). Therefore, the methanolic fraction exhibits potent antioxidant and anti-inflammatory properties along with antidiabetic potential. Keywords: Antidiabetic, Anti-inflammatory, Antioxidant, Tecomella undulata, Ethanolic extract. [Download Article] [Download Certifiate] |