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Abstract

MOLECULAR DOCKING STUDY OF 2,4- THIAZOLIDINEDIONE FOR ANTI-DIABETIC BY USING CADD TOOLS

Rushikesh D. Salunke*, Seema P. Rathod, Shailesh S. Bansode and Ajay R. Rao

ABSTRACT

2,4-Thiazolidinedione (TZD) derivatives are drugs used to treat type 2 diabetes by activating the PPARγ receptor. In this study, we used molecular docking simulations with AutoDock Vina software to examine how different TZD compounds bind to PPARγ. We found key interactions, such as hydrogen bonds and hydrophobic contacts, between the TZD compounds and specific amino acids in the receptor. Our analysis also provided insights into the binding strengths of various TZD derivatives. These findings help us understand how TZD compounds work and could lead to the development of more effective and safer diabetes treatments.

Keywords: 2,4-Thiazolidinedione, Molecular Simulation, PPAR?, Diabetic Mellitus.


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