Abstract

SCIENTIFIC STANDARDIZATION, QUALITY CONTROL, ANTIMICROBIAL POTENTIAL, TOXICOLOGY STUDIES HAVING EFFECTIVE THERAPEUTIC USES OF (WOODFORDIA FRUTICOSA (LINN.) KURZ) FLOWERS PART

Pawan Kumar Sagar*, S. Sajwan and N. Z. Ahmed

ABSTRACT

Standardization and product acceptability is used to describe all measures under taken during the manufacturing process and quality control and quality assurance of drug leading to its reproducible quality. Therefore we need to develop standard validation techniques to standardize and validate of the herbal products and formulations using QC. QA Screening Studies. The drug Woodfordia fruticosa (Linn.) Kurz) is therapeutically useful in the treatment of Anti-pyretic, Anti-pills, Anti-inflammatory, Anti-ulcer, Anti-diarrheal, Anti-Sinus, Anti-Diabetes, Anti-Leukorrhea, Anti-Leprosy, Anti-hyperglycemic activity, Anti-depressant activity, Anti-cancer activity, Antioxidant activity. The single drug WF was Standardization, Quality Control Screening studied in three different batches as per the guidelines of WHO/ AYUSH Protocols basis. Present research study is aimed to evaluate the Standardization and product quality acceptability using physico-chemical parameters; HPTLC fingerprinting as per WHO
guidelines of analyzed parameters. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain Foreign matter, w/w- (0.08 %,0.07%,0.08%), LOD/ Moisture, w/w- (6.054%,6.010% 6.320%), Total ash, w/w- (5.79%,5.82%,6.93%), Acid in-soluble ash, w/w-(0.776%,0.770%,0.778%), Alcohol and water soluble extractive matter, w/v- (12.80%,12.46%, 12.38%) & (24.40%, 24.46%, 24.50%), pH(10% solution) (4.8,4.9,4.8), the HPTLC finger prints showed various spots at 254nm, 366nm Iodine vapours and visible light (M-S reagent). The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis. The QC. findings revealed that the test drug was free from adulterations. The evaluated validated quality standards will be very useful for referential support, validation of the standards of WF, pharmaco-vigilance and providing the quality raw medicine to deprived human being.

Keywords: (Woodfordia fruticosa (Linn) Kurz), Physico-chemical quality QC and QA HPTLC fingerprinting and Unani Compound drug.