Abstract

DESIGN, DEVELOPMENT AND OPTIMIZATION OF MICRO-EMULSION

Mr. Vishnudas K. Lokhande*, Miss. Roshani P. Jaiswal, Dr. M. D. Kshirsagar, Dr. M. A. Channawar and Dr. A. V. Chandewar

ABSTRACT

Micro-emulsions are thermodynamically stable isotopically clear dispersion of two immiscible liquids, such as oil and water, stabilized by an interfacial film of surfactants along with co- surfactants. The aim of this work was to Design, development and optimization of micro-emulsion by using Emulsion Phase Inversion method and liquid paraffin, castor oil, clove oil, orange oil as the oil phase to increase the effectiveness of bacterial treatment through the increase in the penetration of the active compounds. Ten formulations of different concentration of Surfactant, Oil and Co-surfactant were prepared along with fix concentration of preservative then subjected to evaluation and optimized the batch. In vitro release study indicated that the release of drug varied according to concentration of polymers (Surfactant and co-surfactant). In micro-emulsion were prepared using Tween 80, span 80,propylene glycol, liquid paraffin, castor oil, clove oil, orange oil and preservative In vitro release of drug from formulations F8 indicated that a combination of castor oil, orange oil, tween 80, span 80 and Propylene glycol formulations is highly effective in the drug release up to 8 hours. Then formulation F8 was considered as optimized formulation as it showed the bestin-vitro release profile i.e, 83.05 %. The stability study including appearance, colour, pH and drug content of the formulation was studied under various storage conditions.

Keywords: Microemulsion, Thermodynamically stable, Drug Absorption, Bioavailability, Applications, Turmeric micro- emulsion.