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DESIGN, DEVELOPMENT AND OPTIMIZATION OF MICRO-EMULSION
Mr. Vishnudas K. Lokhande*, Miss. Roshani P. Jaiswal, Dr. M. D. Kshirsagar, Dr. M. A. Channawar and Dr. A. V. Chandewar
ABSTRACT
Micro-emulsions are thermodynamically stable isotopically clear dispersion of two immiscible liquids, such as oil and water, stabilized by an interfacial film of surfactants along with co- surfactants. The aim of this work was to Design, development and optimization of micro-emulsion by using Emulsion Phase Inversion method and liquid paraffin, castor oil, clove oil, orange oil as the oil phase to increase the effectiveness of bacterial treatment through the increase in the penetration of the active compounds. Ten formulations of different concentration of Surfactant, Oil and Co-surfactant were prepared along with fix concentration of preservative then subjected to evaluation and optimized the batch. In vitro release study indicated that the release of drug varied according to concentration of polymers (Surfactant and co-surfactant). In micro-emulsion were prepared using Tween 80, span 80, Keywords: Microemulsion, Thermodynamically stable, Drug Absorption, Bioavailability, Applications, Turmeric micro- emulsion. [Download Article] [Download Certifiate] |