Abstract

TRANSDERMAL DRUG DELIVERY SYSTEMS: A COMPREHENSIVE REVIEW ON CURRENT PROGRESS AND FUTURE PERSPECTIVES

Kirankumar R., *Priya Kumari Sinha and Dr. Kavitha P. N.

ABSTRACT

The transdermal drug delivery system (TDDS) is one of the controlled drug delivery systems, with the goal of delivering the drug via the skin at a predetermined and regulated rate. TDDS are adhesive drug-containing devices with a specific surface area that release a predetermined amount of drug to the surface of undamaged skin at a programmed rate until it enters the systemic circulation. The utilization of transdermal drug delivery systems (TDDS) has become a viable method of administering therapeutic substances through the skin barrier while avoiding the negative aspects of oral administration and invasive routes. This review provides an in-depth overview of the TDDS's fundamental ideas, modifications, clinical applications and challenges. It also examines forward to this rapidly evolving subject. Mechanisms of penetration via the skin, formulation approaches,clinical success stories, recent advances, obstacles, and regulatory concerns are some of the significant topics that are mentioned. The main objective of this study is aimed at providing insights into the revolutionary promise of transdermal delivery of medications in contemporary treatment by reviewing existing information and highlighting future directions.

Keywords: Transdermal drug delivery, skin permeation, transdermal patches, micro- needles, iontophoresis, therapeutic applications, tdds components.