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AN ANALYTICAL METHOD FOR THE ESTIMATION OF THIOCOLCHICOSIDE AND ACECLOFENAC IN PHARMACEUTICAL DOSAGE FORMS
Pradeep Kumar*
ABSTRACT
A new RP- HPLC method was developed and validated for the estimation of aceclofenac and thiocolchicoside in their tablet dosage form. The chromatographic separation was carried out by using Agilent Zorbax column (150 × 4.6mm, 5μm). The mobile phase containing the combination of methanol & 0.1% ortho phosphoric acid in the 75: 25 (v/v) ratios. In this method the ow rate used is 1 min/ml for the separation at the detection wavelength of 275 nm. The proposed method was validated according to the ICH guidelines. The method was linear (R2 >0.99), precise (RSD < 2.0%), accurate, simple, sensitive and robust. This method can be successfully used for the routine Keywords: Thiocolchicoside; Aceclofenac; RP- HPLC; Method development; Validation. [Download Article] [Download Certifiate] |