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DETERMINATION OF THE ANTIFUNGAL ACTIVITY OF EXTRACTS OF VERNONIA AMYGDALINA ON MULTI-DRUG RESISTANT CANDIDA SPECIES
Ezejiegu Chinelo K., Bruno Ngozi U., Chukwunwejim Chidimma R., Ezejiegu Emmanuel C., Nwaneri Goodness U. and Ogwaluonye Uchenna C.*
ABSTRACT
Background: Candida species have been associated with human beings for quite long time as harmless commensals. However, they become opportunistic pathogens in immunologically weak and immune compromised patients. Vernonia amygdalina on the other hand has been known to possess ethno-medicinal use. The need for alternative sources targeted at multi-drug resistance organisms gave rise to this study. Objectives The study was carried out to determine the antifungal activity of Vernonia amygdalina extracts on isolated and identified multi-drug resistant (MDR) Candida species. Materials and Methods: Various extracts of Vernonia amygdalina were obtained using standard extraction and fractionation techniques followed by phytochemical screening of the plant extract. Antifungal susceptibility testing using conventional antifungal agents; Itraconazole (10μg/mL), Fluconazole (50μg/mL), 5-Flucytosine (100μg/mL), Amphotericin B (50μg/mL), and Ketoconazole (50μg/mL), were carried out to Keywords: Vernonia amygdalina extracts, Antifungal activity, multi-drug resistant, Candida species. [Download Article] [Download Certifiate] |