Abstract

AN OVERALL REVIEW ON ANALYTICAL AND BIOANALYTICAL METHODS DEVELOPED FOR THE ESTIMATION OF AMLODIPINE BESYLATE AND ENALAPRIL MALEATE

Meiyappan Varadharaj, Janaki Sankarachari Krishnan Nagarajan*, Karthick Rajendran, Lokesh Raja Janarthanan, Jebisel Reba Paul Moses, Avinash Kumar Anil Kumar Singh

ABSTRACT

Amlodipine besylate is a calcium channel blocker and Enalapril Maleate is the maleate salt of Enalapril, the ethyl ester of Enalaprilat, a long-acting angiotensin converting enzyme inhibitor. Enalapril maleate is chemically defined as (S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline, (Z)-2-butenedioate salt (1:1). Several methods like analytical and bioanalytical methods are available for the determination of Amlodipine and Enalapril in pharmaceutical formulation and biological matrices which is published. This entire review article covers many approaches and methods used for the determination of amlodipine and Enalapril in various instruments such as HPLC, LC-MS/MS, UV, UPLC and HPTLC.

Keywords: Amlodipine, Enalapril, HPLC, LC-MS/MS, UV, UPLC.