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FORMULATION AND EVALUATION OF 2% KETOCONAZOLE CREAM
Namrata Udhan*, Vaibhav Waghmare, Poonam Tidke, Nikita Vidhate and Saurabh Mundada
ABSTRACT
This study delves into the formulation and evaluation of a 2% ketoconazole cream for topical antifungal application, leveraging insights from skin physiology, drug profiles, and antifungal classification. The skin, being the largest organ, serves as a crucial barrier against environmental factors, pathogens, and UV radiation. Understanding its complex structure and functions is vital for developing effective topical treatments. Ketoconazole, an imidazole antifungal, holds promise in treating various fungal infections affecting the skin, nails, and other body parts. Its mechanism of action involves inhibiting ergosterol synthesis, disrupting fungal cell membranes, and preventing fungal growth. Formulating ketoconazole into creams offers localized therapy for conditions like dermatophytosis and seborrhea. The experimental work involved preformulation studies to identify ketoconazole's organoleptic characteristics and solubility. The cream formulation included oil-in-water emulsion preparation and solid Keywords: Ketoconazole cream, Anti-Fungal, Skin, Seborrhea. [Download Article] [Download Certifiate] |